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Types Of Glaucoma
....- Open Angle Galucoma
....- Narrow Angle Glaucoma
....- Rubeotic Glaucoma
....- Uveitic Glaucoma
* Tests For Glaucoma
* Treatments For Glaucoma
Keywords
See Also
References
Bibliography



Glaucoma


Disease Of The Eye
Ophthalmology

Newest Version 8 | updated Tue, May 2, 2017 at 22:55:59 | X bytes - by Anonymous.
This article is for information and educational purposes only and is not intended to give medical, legal or professional advice..

Glaucoma is damage to the optic nerve caused by high pressure of the liquid, the aqueous humor, inside the eye.

Introduction

Because the eye is a hollow organ, it needs fluid under pressure in order to maintain its form. The name of this fluid is aqueous humor and its pressure is controlled by maintaining the rate of fluid production and fluid outflow within certain parameters. Fluid is produced by the ciliary body which is behind the iris and then flows out of a ring shaped tissue called the trabecular network located between the iris and the cornea. There are different ways that the functioning of the trabecular network can be impaired. This causes a rise in intraocular pressure (IOP) which leads to mechanical damage to the optic nerve. Normal IOP is considered to be 10 to 21 mmH2O. Treatment begins when the IOP reaches between 25 to 30. A pressure of 30 will cause measurable damage to the optic nerve in one year in half of those who have that pressure. The loss of vision in early glaucoma is in the mid periphery. Because it only affects central vision late in its course, it is basically impossible to notice early glaucoma. Because of this it is important that people over the age of 65 have yearly eye exams.


types of glaucoma


open angle galucoma

This is the most common type of glaucoma. Open angle glaucoma is caused by a loss of function of the trabecular meshwork. Risk factor are age and a familial predisposition. Having relatives with glaucoma increase the risk of getting glaucoma. The name open angle glaucoma refers to how open the angle is. The angle refers to the amount of space between the iris and the cornea. When the angle is very narrow this means that the iris is almost touching the cornea and is at risk for blocking the trabecular meshwork and causing a glaucoma attack. That type of glaucoma is called primary open angle glaucoma. However, the name open angle glaucoma is a little misleading because it does not mean that the angle is actually open. All it means is that the high pressure is not caused by an obstruction of the trabecula by the iris. A person can have both types of glaucoma. He can have open angle glaucoma and narrow angles at the same time. Open angle glaucoma is usually treated by medicated drops in the United States. When the use of multiple drops is not sufficient then various types of surgery may be performed. The rise in pressure is usually very gradual and sometimes does not reach very high levels. However, even somewhat elevated IOP can cause gradual loss of vision which is irreversible. This level of pressure does not cause pain and it is difficult to detect early loss of vision from glaucoma. Because of this it is important form persons over 65 to have yearly screening eye exams.


narrow angle glaucoma

This is a rise in pressure in the eye which often occurs suddenly and is caused by a physical obstruction of the trabecular meshwork by the iris. The pressure can rise over the course of several hours and can reach very high levels which can put the eye at immediate risk for permanent loss of vision. A person who suspect that he/her is having a narrow angle glaucoma attack needs to seek immediate medical attention at an emergency room who has an ophthalmologist on call.


People who are far sighted (who have positive prescriptions, those which make the eyes look larger) are at greater risk for glaucoma attacks because their eyes are smaller than average and the iris and the lens is crowded within a smaller space. Angle closure is the result of a ball valve effect. The lens pushes on the pupil causing a partial blockage of the pupillary opening. This causes the pressure of the fluid behind the lens and iris to rise pushing the lens even more forcefully against the pupil, causing even more blockage. If the pupil is partially dilated, as happens at night, the iris becomes more loose and can trigger an attack. Narrow angle glaucoma caused by the anatomy of the eye is called primary open angle glaucoma. Sometimes an injury in the form of a strong blow to the eye can loosen the lens and cause what is called secondary angle closure. A screening eye exam can detect narrow angles before an attack occurs and a simple laser treatment called a peripheral iridectomy (PI) greatly reduces the risk of a future attack. A PI is a small hole in the iris, usually made by a laser.


If an attack occurs the pressure will be lowered using medicated eye drops and sometimes by the use of oral diuretics to lower the IOP. When the IOP is very high the cornea becomes cloudy and the iris touches the cornea which make giving laser treatment impossible. Once the IOP is lowered and the attack is broken a laser PI can then be performed. However, it is sometimes impossible to break the attack and the PI must be performed in the operating room by means of surgery.


Rubeotic Glaucoma

This is glaucoma caused by the growth of sheets of superficial capillaries over the iris and on to the trabecular meshwork. It is usually the result of untreated diabetic retinopathy or an untreated retinal vein occlusion. The diabetes or the vein occlusion creates poor circulation of blood by different mechanisms. The ischemic tissue then produces vascular endothelial growth factor (VEGF), a peptide hormone or signal which stimulates the growth of capillaries. In most tissues this creates capillaries which correct the ischemia. However, since the eye is hollow, the VEGF accumulates in the vitreous, the jelly in the back of the eye, and this stimulates the growth of tufts of capillaries on the surface of the retina where they can bleed and leak fat and protein. If the production of VEGF is of sufficient quantity it will reach the front of the eye and cause the growth of sheets of capillaries on the surface of the trabecula. The sheets shrink and they can pull the iris up onto the trabecula and cause what is called secondary angle closure glaucoma.


If it the disease is caught early, the underlying retinal disease can be treated with laser photocoagulation. This is a procedure where laser is used to make small burns in the peripheral retina which cause abnormal capillaries to shrink by an unknown mechanism. Furthermore, anti-VEGF medications such as Lucentis or Avastin can be injected into the back of the eye. If the IOP has risen significantly and cannot be controlled with medicated drops then glaucoma surgery is necessary. The common trabeculectomy does not work well for this condition because the opening made to drain the eye can become occluded by the capillary sheets. Instead, a valve or tube shunt is usually placed. This consists of a tube which is inserted into the anterior chamber (the front space) of the eye. The tube is connected to a plate which has a flap-like mechanism which forms a valve that controls the IOP.


uveitic glaucoma

Inflammation in the eye can cause a rise in pressure when such a large number of white blood cells accumulate in the eye that they clog the trabecula. If the eye is inflamed but there are few white blood cells then the pressure can sometimes decrease because the inflammation increases the permeability of the sclera (the white part of the eye) and allows fluid to leak out of the eye. In fact, one family of glaucoma medications, the prostaglandin analogues, activate part of the inflammatory pathway in order to increase aqueous outflow by increasing scleral permeability.


tests for glaucoma


treatments for glaucoma


Keywords

glaucoma


See Also

References

Bibliography

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